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Syncon Inc fap dna vaccine
Fap Dna Vaccine, supplied by Syncon Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/fap+dna+vaccine/syncon+fap+vaccine/pm39892648-182-6-6
Average 90 stars, based on 1 article reviews
fap dna vaccine - by Bioz Stars, 2026-10
90/100 stars

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Modification:

Article Title: Effective design of therapeutic nanovaccines based on tumor neoantigens.
Article Snippet: Neoantigen vaccines are among the most potent immunotherapies for personalized cancer treatment.. Therapeutic vaccines containing tumor-specific neoantigens that elicit specific T cell responses offer the potential for long-term clinical benefits to cancer patients.. Unlike immune-checkpoint inhibitors (ICIs), which rely on preexisting specific T cell responses, personalized neoantigen vaccines not only promote existing specific T cell responses but importantly stimulate the generation of neoantigen-specific T cells, leading to the establishment of a persistent specific memory T cell pool.

Vaccines:

Article Title: Effective design of therapeutic nanovaccines based on tumor neoantigens.
Article Snippet: Neoantigen vaccines are among the most potent immunotherapies for personalized cancer treatment.. Therapeutic vaccines containing tumor-specific neoantigens that elicit specific T cell responses offer the potential for long-term clinical benefits to cancer patients.. Unlike immune-checkpoint inhibitors (ICIs), which rely on preexisting specific T cell responses, personalized neoantigen vaccines not only promote existing specific T cell responses but importantly stimulate the generation of neoantigen-specific T cells, leading to the establishment of a persistent specific memory T cell pool.

Article Title: Research progress in tumor targeted immunotherapy.
Article Snippet: Introduction: Compared with traditional cancer treatment methods, tumor-targeted immunotherapy can combine targeted therapy and immunotherapy with long-lasting responses to achieve synergistic therapy, which brings hope to the complete cure of cancer.. Areas covered: This review summarizes the newest and most up-to-date advances in tumor-targeted immunotherapy, including tumor-associated macrophages (TAMs) targeted immunotherapy, regulatory T (Treg) cells targeted immunotherapy, tumor-associated fibroblasts (TAFs) targeted immunotherapy and immune checkpoints targeted immunotherapy.. Expert opinion: Immunotherapy can restore anti-tumor immunity in the tumor microenvironment and produce a lasting immune surveillance effect.

Article Title: Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials.
Article Snippet: Recently, a synthetic consensus (SynCon) FAP DNA vaccine has displayed superiority at breaking immune tolerance compared to the native FAP immunogen in genetically diverse mice. .. The SynCon FAP DNA vaccine synergized with other tumor-antigen-specific DNA vaccines showed a stronger anti-tumor activity than monotherapy, and the SynCon FAP DNA vaccine itself exerted remarkable antitumor effect in the TC-1, Brpkp110, and TSA tumor models [216]. ..

Biomarker Discovery:

Article Title: Effective design of therapeutic nanovaccines based on tumor neoantigens.
Article Snippet: Neoantigen vaccines are among the most potent immunotherapies for personalized cancer treatment.. Therapeutic vaccines containing tumor-specific neoantigens that elicit specific T cell responses offer the potential for long-term clinical benefits to cancer patients.. Unlike immune-checkpoint inhibitors (ICIs), which rely on preexisting specific T cell responses, personalized neoantigen vaccines not only promote existing specific T cell responses but importantly stimulate the generation of neoantigen-specific T cells, leading to the establishment of a persistent specific memory T cell pool.

Immunopeptidomics:

Article Title: Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice
Article Snippet: .. © 2017 American Association for Cancerclincancerres.aacrjournals.org Downloaded from 8 Immunogenicity of SynCon FAP DNA vaccine in C57Bl/6 mice In order to determine whether the SynCon FAP DNA vaccine was immunogenic and capable of breaking tolerance in mice, we immunized C57Bl/6 mice with different doses of SynCon FAP DNA vaccine (5μg, 10μg, 25μg and 50μg) by intramuscular injection with EP (Figure 1A). ..

Injection:

Article Title: Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice
Article Snippet: .. © 2017 American Association for Cancerclincancerres.aacrjournals.org Downloaded from 8 Immunogenicity of SynCon FAP DNA vaccine in C57Bl/6 mice In order to determine whether the SynCon FAP DNA vaccine was immunogenic and capable of breaking tolerance in mice, we immunized C57Bl/6 mice with different doses of SynCon FAP DNA vaccine (5μg, 10μg, 25μg and 50μg) by intramuscular injection with EP (Figure 1A). ..

Activity Assay:

Article Title: Define cancer-associated fibroblasts (CAFs) in the tumor microenvironment: new opportunities in cancer immunotherapy and advances in clinical trials.
Article Snippet: Recently, a synthetic consensus (SynCon) FAP DNA vaccine has displayed superiority at breaking immune tolerance compared to the native FAP immunogen in genetically diverse mice. .. The SynCon FAP DNA vaccine synergized with other tumor-antigen-specific DNA vaccines showed a stronger anti-tumor activity than monotherapy, and the SynCon FAP DNA vaccine itself exerted remarkable antitumor effect in the TC-1, Brpkp110, and TSA tumor models [216]. ..

other:

Article Title: Alteration of the Tumor Stroma Using a Consensus DNA Vaccine Targeting Fibroblast Activation Protein (FAP) Synergizes with Antitumor Vaccine Therapy in Mice
Article Snippet: While variability was observed between the mice, the overall immune response was higher for the SynCon FAP immunized group compared to the native FAP immunized group (Figure 2A,B).



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